Regular price $53.95


Servings Per Container: 

Ostera, in combination with a Mediterraneanstyle, low-glycemic-load diet and aerobic exercise, has been clinically shown in postmenopausal women to beneficially influence key markers of bone remodeling more than diet and exercise alone.*


  • Promotes healthy bone remodeling biomarkers to support bone quality and integrity*
  • Clinically shown in a study of postmenopausal women with low estrogen levels to:*


    • Beneficially influence key markers of bone remodeling
    • Positively influence osteocalcin, a key marker of bone remodeling rate*
    • Offer more effectiveness than diet and exercise alone
  • Features selective kinase response modulators (SKRMs) in the form of RIAA from hops, as well as the herb berberine and vitamins D and K to nutritionally support healthy bone remodeling during the aging process*
Serving Size:

1 Tablet

Ingredient Amount Daily Value
Vitamin D (as cholecalciferol) 500 IU  125% 
Vitamin K (as phytonadione) 500 mcg  625% 
Berberine HCl (Phellodendron amurense bark extract) 90 mg 
Reduced Iso-Alpha Acids Complex (from hops extract, Humulus lupulus L.) 370 mg 

Other Ingredients: Microcrystalline cellulose, stearic acid (vegetable), croscarmellose sodium, calcium silicate, silica, and coating (hypromellose, medium chain triglycerides , and hydroxypropylcellulose).

Directions: Take one tablet twice daily, or as directed by your healthcare practitioner.

This product is non-GMO and gluten free.


How does Ostera® compare to other products or approaches?

As a nutraceutical , this product is formulated to complement diet and exercise recommendations to promote bone health, but varies significantly from common bone health formulas that contain calcium. This product is intended as a complement to (not a substitute for) supplemental calcium recommendations. Ostera offers an approach for a unique target in postmenopausal bone health support, and may be the only nutritional supplement specifically designed to support healthy bone remodeling.*

How does Ostera® work?

This product contains a science-based blend of ingredients to promote healthy bone remodeling, which supports the bone architecture that holds calcium and other minerals. Bone is living tissue, and the remodeling process helps remove old or damaged tissue and build new tissue. This process slows down with age and can also be influenced by estrogen decline in menopause and a subtle increase (associated with age or unhealthy lifestyle patterns) in cytokines that signal various body activities. Cellular studies showed that the RIAA in Ostera acts as a selective kinase (specialized enzyme) response modulator (SKRM) in signaling processes in the body related to bone health. (Balanced kinase signaling helps to maintain healthy function, and SKRMs can enhance "healthy" signals from a targeted dietary plan.) Berberine and vitamins D and K also help nutritionally support healthy bone remodeling during the aging process.*

How long is Ostera® typically recommended?

This formula was designed for daily support of healthy bone remodeling—a continual process that influences the quality of bone structure. In a 12-week study at the FMRC, the Ostera program (including a low-glycemic-load diet and regular exercise) was shown to be more effective than diet and exercise alone in positively influencing markers of bone remodeling in postmenopausal women with low estrogen levels. Individual results may vary. Your health care professional may recommend regular follow-up visits to re-evaluate markers of bone health. For best results, follow your health care professional's guidelines.*

Who would benefit from Ostera®?

Health care professionals typically recommend this product to postmenopausal women as part of a more comprehensive bone health program, specifically to promote healthy bone remodeling and support the integrity (quality) of the bone matrix (the architecture where minerals are deposited). This product may also be recommended for men or women prior to menopause, where appropriate. This product is not intended as a substitute for bone mineralization (density) support, such as MCHC calcium.*

Why is Ostera® safe?

It contains a blend of natural ingredients with an excellent safety profile. Plus, Metagenics' manufacturing facility has 3 certifications for good manufacturing practices to ensure the highest quality. Key active ingredients in this formula were developed through the ExpresSyn Process® that sets a new standard in clinical certainty for natural products via demonstrated efficacy, bioavailability , and a high level of predicted safety. Ostera has been clinically reviewed at the FMRC. (This product is not recommended for those taking anticoagulant medications.)